hrp0086wg2.4 | ESPE Obesity Working Group (OWG) | ESPE2016

Tanycyte Transport of Leptin into the Hypothalamus: Implications in Leptin Resistance

Prevot Vincent

Background: The survival of an organism relies on its ability to promptly, effectively and reproducibly communicate with brain networks that control food intake and energy homeostasis. To achieve this, circulating factors of hunger and satiety reflecting nutrient availability must cross the blood-brain barrier (BBB) to reach effectors neurons.Objective and hypotheses: Here I will discuss the key role played in this process by a peculiar type of glial cel...